Category:

Research Tool

Description:

Different forms of heart enlargement (hypertrophy) with different "active gene profiles" are caused, for example, during endurance training (healthy) or narrow/stenosis of the arteries (heart failure risk). The inventors generated a genetically modified mouse with a hypertrophic heart that responds to surgically-induced arterial stenosis with further hypertrophy, but without anticipated heart failure. Since hypertrophic heart disease comprises up to 70% of cardiovascular diseases (2 of 5 deaths in the United States), understanding the active gene profile in these mice should lead to the development of drugs to prevent heart failure and save lives.

Potential Applications:

• Novel Knockout Mouse
• Allows the study of hypertrophy
• First of its kind

Inventor(s):

Drs. D. Spyropoulos; M. Zile; D. Menick; C. Baicu; C. Beeson; F. Bartel

Relevent Publications:

Submitted for publication

Patent Status:

Research Tool

Availability:

Available for:
exclusive
non-exclusive
licensing.

Technology Status:

Mouse model is produced and stable. Breeding pairs are ready to be sent.

Licensing Contact:

Ryan N. Fiorini, MBA, Ph.D.
MUSC Foundation for Research Development
PO Box 250828
Charleston, SC 29425
843.876.1906
fiorinir@musc.edu