Category:

Novel Therapeutic

Description:

Researchers at the Medical University of South Carolina and the University of Nevada have discovered a protein (produced recombinantly) shown to pit ice sheets and inhibit recrystalization (gathering of small ice crystals into larger crystals).  Semi-pure native preparations of similar proteins have shown to decrease hemolysis of red blood cells when cells were frozen, suggesting a possible protective role of these proteins in freeze-thaw injury. 

While similar proteins exist naturally, this is the first time a recombinant ice binding protein has been produced.

Potential Applications:

• Can enhance mammalian cell viability during freezing at cold temperatures such as liquid nitrogen
• Prevent solid ice accumulation on surfaces by interacting with ice crystals to inhibit recrystallization (incorporated into paints and resins)
• Can be utilized in the food industry where frozen cream based foods, thereby preserving the integrity and the product over long periods of freeze storage

Inventor(s):

Drs. M. Janech & J. Raymond

Patent Status:

Availability:

Available for:
exclusive
non-exclusive
licensing.

Technology Status:

Data and results available with execution of a confidentiality agreement

Licensing Contact:

Ryan N. Fiorini, Ph.D., MBA, MHA
MUSC Foundation for Research Development
PO Box 250828
Charleston, SC 29425
843.876.1906
fiorinir@musc.edu