Category:

New Use Therapeutic

Description:

The present invention provides an isolated mammalian receptor termed cubilin (and associated proteins) which specifically binds high density lipoprotein (HDL) holoparticle and mediates endocytosis leading to lysosomal degradation of HDL. In addition, the present invention provides a method of screening a substance for the ability to modulate the HDL holoparticle binding and/or internalization activity of the receptor of this invention. The technology would be used for the design of compounds, drugs, or therapeutic agents that regulate the activity or expression of the HDL endocytosis receptor.

Potential Applications:

Inventor(s):

Drs. W.S. Argraves and S. Hammad

Patent Status:

Availability:

Available for:
exclusive
non-exclusive
licensing.

Technology Status:

Licensing Contact:

Ryan N. Fiorini, Ph.D., MBA, MHA
MUSC Foundation for Research Development
PO Box 250828
Charleston, SC 29425
843.876.1906
fiorinir@musc.edu